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Acute radiation syndrome (ARS) or sickness or poisoning or toxicity is induced after a whole body exposure of men to high doses of radiation between 1-12Gy. First symptoms are from the gastrointestinal system, which together with bone marrow are the most sensitive parts of our body. Chronic radiation syndrome (CRS) may be induced by smaller than 1Gy radiation doses or after a mild form of ARS. ...

Acute radiation syndrome affects military personnel and civilians following the uncontrolled dispersal of radiation, such as that caused by detonation of nuclear devices and inappropriate medical treatments. Therefore, there is a growing need for medical interventions that facilitate the improved recovery of victims and patients. One promising approach may be cell therapy, which, when appropria...

Health problems after a nuclear crisis are aninteresting issue in medicine. After the recentJapanese nuclear crisis, several health issuesunderwent monitoring. There are few considerationson mucocutaneous diseases. Indeed, there is nodoubt that the skin and mucocutaneous issues arethe main organs affected by leaked radiations. It isimportant to take care of mucocutaneous lesionsin acute radiati...

Acute radiation exposure induces apoptosis of tissues in the hematopoietic, digestive, cutaneous, cardiovascular and nervous systems; extensive apoptosis of these tissues ultimately leads to acute radiation syndrome. A novel strategy for developing radiation countermeasures has been to imitate the genetic mechanisms acquired by radiation-resistant tumors. Two mechanisms that underlie this abili...

INTRODUCTION PATHOPHYSIOLOGY Hematopoietic Syndrome Gastrointestinal Syndrome Neurovascular Syndrome DETERMINANTS OF RADIATION EFFECTS ON HUMANS Lethality Curve Influence of Trauma on LD50 Effect of Clinical Support on the LD50 Dose Effect Curve CLINICAL ASPECTS OF THE US CRITICALITY EXPERIENCE Clinical Course of the Criticality Cases CURRENT TREATMENT OF ACUTE RADIATION SYNDROME Supportive Car...

Pharmacological mitigation of injuries caused by high-dose ionizing radiation is an unsolved medical problem. A specific nonlipid agonist of the type 2 G protein coupled receptor for lysophosphatidic acid (LPA2) 2-[4-(1,3-dioxo-1H,3H-benzoisoquinolin-2-yl)butylsulfamoyl]benzoic acid (DBIBB) when administered with a postirradiation delay of up to 72 hr reduced mortality of C57BL/6 mice but not L...